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Take acetaminophen and hydrocodone exactly as directed by your doctor. Take each dose with a full glass of water. Take acetaminophen and hydrocodone with food or milk if it upsets your stomach. Never take more of this medication than is prescribed for you. Too much acetaminophen and hydrocodone could be very harmful. Do not stop taking acetaminophen and hydrocodone suddenly if you have been taking it continuously for more than 5 to 7 days. Stopping suddenly could cause withdrawal symptoms and make you feel uncomfortable. Your doctor may want to gradually reduce your dose.